Citrix XenApp (formerly Citrix MetaFrame Server and Citrix Presentation Server) is a remote access/application publishing product that allows people to connect to applications available from central servers. One advantage of publishing applications using XenApp is that it lets people connect to these applications remotely, from their homes, airport Internet kiosks, smart phones, and other devices outside of their corporate networks. From an end-user perspective, users can log in to their corporate network from, for example, an airport kiosk, see all of the applications they would see everyday at work, including Outlook email and any internal applications, and access them from the kiosk in a secure environment. To the user, the application would appear as if it was installed and running on their computer (seamless desktop integration), whereas in reality, the application is running on XenApp, usually hosted in their corporate environment.

Networks that use this software are reminiscent of the mainframe-terminal system, where a central powerful computer does most of the processing work and smaller, much less powerful machines provide the user interface.

Some academic institutions use Citrix XenApp to provide their students and faculty with remote access to applications running on campus servers.